The human liver manufactures adequate amounts to fulfill the need not met in the diet. Some whole food nutritionists may believe that people who are deficient  in B vitamins, selenium, vitamin C, or vitamin E may not be able to make as much coenzyme Q10 as they need since all these nutrients  are required in order to produce it.

Coenzyme Q10 is normally produced by the human body, although deficiency may occur in patients with impaired CoQ10 biosynthesis due to severe metabolic or mitochondrial disorders, not enough dietary CoQ10 intake, or too much CoQ10 use by the body. Depending on the cause of CoQ10 deficiency, supplementation or increased dietary intake of CoQ10 and the vitamins and minerals needed to produce CoQ10 may be effective.